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Degraders: A New Drug Discovery Approach - School of Pharmacy
Professor Weiping Tang harnesses cells’ natural protein disposal system to destroy disease-causing proteins.
wisc.edu
2023年10月26日
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SOLVED:Testing the metabolic stability of compounds used in drugs is the cornerstone of new drug discovery. Two important values computed from the testing phase are the fraction of compound unbound to plasma ( fup) and the fraction of compound unbound to microsomes (fumic). A key formula for assessing stability assumes that the fup/fumic ratio is 1 . Pharmacologists at Pfizer Global Research and Development investigated this phenomenon and reported the results in ACS Medicinal Chemistry Letters
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