Macrophages in immunoregulation and therapeutics
2023年5月22日 · Macrophages possess binary M1/M2 macrophage polarization settings, which perform a central role in an array of immune tasks via intrinsic signal cascades and, therefore, must be precisely...
Differences Between M1 and M2 Macrophages | Charles River
M1 macrophages produce nitric oxide (NO) or reactive oxygen intermediates (ROI) to protect against bacteria and viruses. M2 macrophages are alternatively activated by exposure to certain cytokines such as IL-4, IL-10, or IL-13. M2 macrophages will produce either polyamines to induce proliferation or proline to induce collagen production.
Macrophages: shapes and functions - PMC - National Center for ...
2022年3月10日 · M1/M2 macrophage polarization. Monocytes/macrophages are characterized by a strong plasticity and heterogeneity. Dependent on the surrounding micromilieu and the immunological context, macrophages can acquire distinct functional characteristics through a process called polarization.
M1 Macrophage and M1/M2 ratio defined by transcriptomic …
2020年10月6日 · In the current study, we defined “M1” macrophage and “M1”/“M2” ratio by transcriptomic signatures using xCell. We investigated the association between high level of “M1” macrophage or...
Macrophage M1/M2 polarization - PubMed
2020年6月15日 · Improving the inflammatory environment by modulating the activation state of macrophages is an effective method for the treatment of diseases. In this review, we analyzed the mechanism of macrophage polarization from the tumor microenvironment, nanocarriers, nuclear receptor PPARγ, phagocytosis, NF-κB signaling pathways, and other pathways.
Classification of M1/M2-polarized human macrophages by label …
2017年8月21日 · Human monocyte derived macrophages have been investigated using hyperspectral reflectance confocal microscopy, and hyperspectral datasets have been analysed in terms of M1 vs. M2 polarization by...
Anatomy of a Discovery: M1 and M2 Macrophages - PMC
2015年5月5日 · M1 and M2 macrophage-type responses kill or repair in vivo. The unique ability of macrophages to make these polar opposite type of responses provides primary host protection and maintains tissue homeostasis throughout the animal kingdom.
New insights into M1/M2 macrophages: key modulators in …
2021年7月21日 · In summary, M1 and M2 macrophages are functionally distinct and key modulators in host immune system against tumors. In contrast to M1, M2 mechanisms incorporate location-related, mutually connected, and cascade-like reactions.
Global characterization of macrophage polarization mechanisms …
2021年11月2日 · Here, global quantitative time-course proteomics and phosphoproteomics during the first 24 h of M1- versus M2-type macrophage polarization, combined with transcriptomics, provide a detailed picture of changes in cellular functions and metabolic pathways that occur with each polarization process.
M1 and M2 Macrophages: Oracles of Health and Disease
M1/M2 describes the two major and opposing activities of macrophages. M1 activity inhibits cell proliferation and causes tissue damage while M2 activity promotes cell proliferation and tissue repair.
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