Histone - Wikipedia
Histones prevent DNA from becoming tangled and protect it from DNA damage. In addition, histones play important roles in gene regulation and DNA replication. Without histones, unwound DNA in chromosomes would be very long.
Histone - National Human Genome Research Institute
1 天前 · A histone is a protein that provides structural support for a chromosome. Each chromosome contains a long molecule of DNA, which must fit into the cell nucleus. To do that, the DNA wraps around complexes of histone proteins, giving the chromosome a …
DNA Packaging: Nucleosomes and Chromatin - Nature
Chromosomal DNA is packaged inside microscopic nuclei with the help of histones. These are positively-charged proteins that strongly adhere to negatively-charged DNA and form complexes called ...
Histone acetylation and deacetylation - Wikipedia
The mechanism for acetylation and deacetylation takes place on the NH 3+ groups of lysine amino acid residues. These residues are located on the tails of histones that make up the nucleosome of packaged dsDNA. The process is aided by factors known as histone acetyltransferases (HATs).
Histone | DNA, Chromatin & Proteins | Britannica
Histone, any of a group of simple alkaline proteins usually occurring in cell nuclei, combined ionically with DNA (deoxyribonucleic acid) to form nucleoproteins (q.v.). A unit in which a molecule of a histone is bound to a segment of the DNA chain of genetic material is termed a nucleosome.
Histone H2A - Wikipedia
Histone H2A is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. The other histone proteins are: H1, H2B, H3 and H4. The crystal structure of the nucleosome core particle consisting of H2A, H2B, H3 and H4 core histones, and DNA. The view is from the top through the superhelical axis.
DNA-Histone Cross-Links: Formation and Repair - PMC
2020年12月21日 · Electrostatic interactions and hydrogen bonds between histones and DNA are vital for the stable organization of nucleosome core particles, and for the folding of chromatin into more compact structures, which regulate gene expression via controlled access to DNA.
histone / histones | Learn Science at Scitable - Nature
Histones are a family of basic proteins that associate with DNA in the nucleus and help condense it into chromatin. Nuclear DNA does not appear in free linear strands; it is highly condensed...
Histones: At the Crossroads of Peptide and Protein Chemistry
2015年3月3日 · Spectroscopic probes have played a central role in characterizing protein structure and function, and the ability to introduce labels into DNA or by cysteine conjugation into histones makes nucleosomes attractive targets for diverse types of spectroscopy.
Histone exchange, chromatin structure and the regulation of ...
2015年2月4日 · Access of RNA polymerase II to DNA is regulated by the ordered disassembly of nucleosomes and by histone exchange. Chromatin modifications, chromatin remodellers, histone chaperones and...
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