Nature Reviews Drug Discovery
2024年8月14日 · This Review identifies key challenges in assessing and mitigating the risk of immunogenicity, particularly the generation of anti-drug antibodies, and suggests pragmatic steps to address them ...
Drug discovery - Wikipedia
In the fields of medicine, biotechnology, and pharmacology, drug discovery is the process by which new candidate medications are discovered. [1] Historically, drugs were discovered by identifying the active ingredient from traditional remedies or …
Drug discovery - Latest research and news | Nature
2024年10月7日 · Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and...
An overview of drug discovery and development - PubMed
Traditionally, drug discovery relied on natural products as the main source of new drug entities, but was later shifted toward high-throughput synthesis and combinatorial chemistry-based development. New technologies such as ultra-high-throughput drug screening and artificial intelligence are being heavily employed to reduce the cost and the ...
Drug Discovery Today | Journal | ScienceDirect.com by Elsevier
Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how …. View full aims & scope.
A guide to drug discovery - Nature
2003年1月1日 · This article presents a set of principles for disease-relevant assays, and discusses new opportunities for exploiting advances in cell-based assay technologies in drug discovery, including...
Drug Discovery - an overview | ScienceDirect Topics
Drug discovery can be described as the process of identifying chemical entities that have the potential to become therapeutic agents. The important considerations in drug discovery include definition of drug targets, generating diversity, definition of lead structures, and qualifying leads for transition to early trials.
A comprehensive review of discovery and development of drugs …
2024年1月1日 · Drug discovery and development is a process that involves the identification, optimization, pre-clinical and clinical studies to extensively test and characterize the new drug molecule for its pharmacological properties and toxicity profile (Sleire et al., 2017).
Frontiers | Drug discovery and development: introduction to the …
2023年5月23日 · Finding new drugs usually consists of five main stages: 1) a pre-discovery stage in which basic research is performed to try to understand the mechanisms leading to diseases and propose possible targets (e.g., proteins); 2) the drug discovery stage, during which scientists search for molecules (two main large families, small molecules and ...
Full article: Artificial intelligence in drug discovery: recent ...
2021年4月2日 · Ligand-based drug discovery built on novel deep learning techniques, such as message-passing neural networks, could facilitate the discovery of new chemical entities.