Clarification using depth filtration is widely adopted in the manufacturing of monoclonal antibody (mAbs) as the first step to remove the cells and other colloids to prepare cell culture harvest for downstream chromatography and purification.
Depth filtration that delivers reliability and versatility | Solventum
Deep within your bioprocessing journey, depth filtration takes the stage, removing particles and impurities to uphold product purity and yield. You need reliable, proven solutions that optimize process performance and uphold product quality no matter the market you serve, whether it's pharmaceuticals, biotechnology, and beyond.
Traditional depth filtration systems utilize lenticular style cartridge filters and a vertical filtration flow path to allow easy access to process liquids and efficient utilization of
Depth filtration in bioprocessing — new opportunities for an …
2021年12月1日 · This review highlights the key principles, developments, and applications of depth filtration systems, including growing opportunities for use of depth filtration for both initial clarification and for treatment of in-process streams to reduce host cell proteins and remove key foulants to improve the overall performance of the downstream process.
Depth filtration - Cytiva
Selection and design of depth filtration process to minimize cell lysis and particle counts. A compact and economical solution for maximal virus yield and robust protection of downstream purification steps. Impact of feed stream and filter characteristics on clarification performance and …
Single-Use Depth Filters: Application in Clarifying Industrial Cell ...
2017年1月20日 · Flow filtration is the simplest procedure for clarifying cell culture supernatants of nearly unlimited scale. Tangential-flow filtration (TFF) is often used based on its ability to counteract continually the formation of a surface layer …
Depth filtration in bioprocessing — new opportunities for an old …
2022年7月21日 · This review highlights the key principles, developments, and applications of depth filtration systems, including growing opportunities for use of depth filtration for both initial clarification and for treatment of in-process streams to reduce host cell proteins and remove key foulants to improve the overall performance of the downstream process.
DNA RETENTION ON DEPTH FILTERS - PMC
Depth filtration is a commonly-used bioprocessing unit operation for harvest clarification that reduces the levels of process- and product-related impurities such as cell debris, host-cell proteins, nucleic acids and protein aggregates.
Depth filtration: Cell clarification of bioreactor offloads
2006年9月1日 · Depth filtration for the removal and clarification of CHO cell & cell debris from cell laden bioreactor off-load, plays an increasingly important role in Bioprocesses today. These Lenticular (depth) filters are a direct adaptation from pure cotton fibre type filters of bygone years, to the graded density resin bonded filters of today 1.
Depth filter - Wikipedia
The main purpose of a depth filter is to act as a clarifier, separating suspended solids from a bulk flow liquid stream and as a result is employed within the final stage of a separation process. By convention, depth filters consist of a single outlet stream of a purified liquid retaining the waste particles within its system.