Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in …
Prolonged infusion of β-lactam antibiotics was associated with a reduced risk of intensive care unit mortality (risk ratio, 0.84; 95% credible interval, 0.70-0.97; high certainty) and an increase in clinical cure (risk ratio, 1.16; 95% credible interval, 1.07-1.31; moderate certainty).
Continuous vs Intermittent Meropenem Administration in Critically …
This clinical trial compares the efficacy of continuous vs intermittent infusion of a β-lactam antibiotic (piperacillin-tazobactam or meropenem) in decreasing all-cause mortality at 90 days in critically ill patients with sepsis.
A Randomized Trial of Albumin Infusions in Hospitalized Patients …
2021年3月3日 · We conducted a randomized, multicenter, open-label, parallel-group trial involving hospitalized patients with decompensated cirrhosis who had a serum albumin level of less than 30 g per liter at...
Continuous vs Intermittent β-Lactam Antibiotic ... - JAMA Network
This clinical trial compares the efficacy of continuous vs intermittent infusion of a β-lactam antibiotic (piperacillin-tazobactam or meropenem) in
Continuous vs Intermittent β-Lactam Antibiotic Infusions in …
2024年8月27日 · Objective: To evaluate whether continuous vs intermittent infusion of a β-lactam antibiotic (piperacillin-tazobactam or meropenem) results in decreased all-cause mortality at 90 days in critically ill patients with sepsis.
Bezlotoxumab for Prevention of Recurrent Clostridium difficile ...
2017年1月26日 · We conducted two double-blind, randomized, placebo-controlled, phase 3 trials, MODIFY I and MODIFY II, involving 2655 adults receiving oral standard-of-care antibiotics for primary or recurrent...
Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic ...
2018年6月13日 · We conducted a 13-center, randomized, controlled trial that examined the effects of the rate of administration and the sodium chloride content of intravenous fluids on neurologic outcomes in...
Prolonged vs intermittent intravenous infusion of β-lactam …
2023年12月5日 · We conducted this systematic review of randomized clinical trials (RCTs) with meta-analysis and trial sequential analysis (TSA) to compare the effects of prolonged vs intermittent intravenous infusion of β-lactam antibiotics for patients with sepsis.
Prolonged β-Lactam Infusions and Patients Outcomes: Insights …
2024年7月28日 · Results showed no significant difference between the continuous and intermittent groups, with mortality rates of 24.9% and 26.8%, respectively. 1 Secondary outcomes were clinical cure up to 14 days after randomization and new acquisition, colonization, or infection with a multidrug resistant organism or Clostridioides difficile infection up to ...
Effect of Continuous Infusion of Hypertonic Saline vs Standard …
We conducted an investigator-initiated multicenter, parallel-group, open-label, randomized clinical trial with blinded adjudication of the primary outcome to investigate the effects of continuous infusion of hypertonic saline solution in addition to standard care in patients with moderate to severe TBI.
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