Impact of CRISPR in cancer drug discovery | Science - AAAS
2024年10月24日 · CRISPR-based screens of cancer cell lines, and phenotypic readouts such as cell growth, can facilitate the discovery of genetic interactions that could be therapeutic targets. Machine learning of these datasets and other information can be used to model drug effects on tumor microenvironments and better predict effects on patients.
Computer-aided drug design in anti-cancer drug discovery: …
2023年1月1日 · To provide effective therapies for cancer patients, traditional drug discovery has been used to design and develop drugs that can eradicate cancer cells with minimal harm to healthy cells. This process involves the identification of targets, chemical synthesis of compounds, preclinical testing in vitro and animal models and toxicity assessment.
Artificial intelligence in cancer target identification and drug discovery
2022年5月10日 · Artificial intelligence is an advanced method to identify novel anticancer targets and discover novel drugs from biology networks because the networks can effectively preserve and...
Enhancing Drug Discovery and Development - NCI - National Cancer …
The discovery and development of new therapeutic agents for cancer is essential for continued progress against the disease. Historically, NCI has played a vital role in cancer drug discovery and development, and, today, that role continues.
Emerging concepts in drug discovery for cancer therapy - PMC
This thematic issue provides an overview of recent advances in cancer drug discovery, in areas such as fragment‐based drug development, targeting the DNA damage response or the MYC oncogene, senolytic therapies and computational tools that facilitate drug discovery and the selection of treatments in personalized medicine.
Emerging Trends in Cancer Drug Discovery—From Drugging the …
2021年4月1日 · We illustrate this notion with several recent cancer drug-discovery examples, while also giving an outlook on the opportunities offered by newer modalities such as chemically induced proximity and direct targeting of RNA.
Artificial intelligence in cancer target identification and drug discovery
2022年5月10日 · Artificial intelligence is an advanced method to identify novel anticancer targets and discover novel drugs from biology networks because the networks can effectively preserve and quantify the interaction between components of …
Innovating cancer drug discovery with refined phenotypic screens
2024年8月1日 · Innovations in culturing patient-derived cancer cells in a tumor-relevant microenvironment have improved the disease relevance of findings. Technological advances for high-throughput screening, ranging from imaging to omics, have increased the information content of readouts and strengthened discovery by phenotype-focused approaches.
Cancer Drug Discovery and Anticancer Drug Development
2016年11月13日 · Molecular-targeting has now become the new drug discovery paradigm that drives the development of novel anticancer therapeutic modalities and influences how anticancer drug discovery is approached today.
Cancer Drug Discovery: A Molecular Journey to Targeted Treatment
2022年4月14日 · Cancer drug discovery has made great advances since its earliest steps. Cytotoxic drugs affect healthy cells, as well as the tumor, and thus give rise to a multitude of side effects. To counter this, the focus has shifted to targeted approaches that exploit molecular characteristics that are unique to the tumor.