Acyl-CoA metabolism and partitioning - PubMed
网页Long-chain fatty acyl-coenzyme As (CoAs) are critical regulatory molecules and metabolic intermediates. The initial step in their synthesis is the activation of fatty acids by one of 13 long-chain acyl-CoA synthetase isoforms.
Coenzyme A biosynthesis: mechanisms of regulation, function
网页2024年6月13日 · Within the mitochondrial matrix, acetyl-CoA, malonyl-CoA and distinct fatty acid synthesis enzymes are required for assembly of electron transport chain complexes, mitochondrial...
Acyl-CoA Metabolism and Partitioning - PMC - National Center …
网页Their acyl-CoA products regulate metabolic enzymes and signaling pathways, become oxidized to provide cellular energy, and are incorporated into acylated proteins and complex lipids like triacylglycerol, phospholipids, and cholesterol esters.
Fatty acid metabolism and acyl-CoA synthetases in the liver …
网页2021年11月11日 · Generated acyl-CoA as a raw material initiates the subsequent metabolism pathway to produce energy or synthesize diverse complex lipids. In addition, acyl-CoA can be deactivated to free FAs and CoA, and this process is mediated by acyl-CoA thioesterases (ACOTs).
Acyl-CoA - an overview | ScienceDirect Topics
网页Acyl-CoA. Acyl-CoA thioesterases (ACOTs) constitute a family of enzymes that hydrolyze fatty acyl-CoAs to form FFA and CoA. Although biochemically and biophysically well characterized, the metabolic functions of these enzymes remain incompletely understood.
Acyl-CoA - an overview | ScienceDirect Topics
网页Acyl-CoAs are intermediates of lipid catabolism and anabolism in eukaryotic cells, including beta-oxidation (which occurs within mitochondria and peroxisomes), and the biosynthesis/remodeling of lipids (e.g. mono-, di-, and triglycerides, phospholipids and …
Acyl-CoA: Functions, Metabolism, and Analytical Methods
网页Acyl-CoA analysis plays a critical role in understanding the effects of nutrition and dietary interventions on cellular metabolism. Researchers can assess changes in acyl-CoA profiles in response to different dietary components, such …
Quantitative subcellular acyl-CoA analysis reveals distinct nuclear ...
网页This approach represents a critical advance that enables the direct analysis of the mechanistic relationship between acyl-CoA supply and functional outputs of acyl-CoA metabolism including protein acylation and metabolic pathway activity, which are distinct between subcellular compartments.
Acyl-CoA Metabolism and Partitioning - Annual Reviews
网页Acyl-CoA Metabolism and Partitioning. Long-chain fatty acyl-coenzyme As (CoAs) are critical regulatory molecules and metabolic intermediates. The initial step in their synthesis is the activation of fatty acids by one of 13 long-chain acyl-CoA synthetase isoforms.
Acyl-CoA synthesis, lipid metabolism and lipotoxicity - PMC
网页In this review, we cover the evidence for the involvement of acyl-CoAs in what has been termed lipotoxicity, the regulation of the acyl-CoA synthetases, and the emerging functional roles of acyl-CoAs in the major tissues that contribute to insulin resistance and lipotoxicity, adipose, liver, heart and pancreas. Go to:
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