ZAP70 - Wikipedia
ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein normally expressed near the surface membrane of lymphocytes (T cells, natural killer cells, and a subset of B cells). [5] It is most prominently known to be recruited upon antigen binding to the T cell receptor (TCR), and it plays a critical role in T cell signaling.
ZAP-70: An Essential Kinase in T-cell Signaling - PMC
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease.
ZAP-70: an essential kinase in T-cell signaling - PubMed
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease.
ZAP-70 expression identifies a chronic lymphocytic leukemia …
2003年6月15日 · ZAP-70 expression correctly predicted IgVH mutation status in 93% of patients. ZAP-70 expression and IgVH mutation status were comparable in their ability to predict time to treatment requirement following diagnosis.
ZAP-70 constitutively regulates gene expression and protein …
2021年7月1日 · ZAP-70 is essential to maintain a constitutive survival signal for CLL cells and is directly involved in the expression of CCL3 and CCL4. Upon BCR activation, ZAP-70 increasingly forms complexes with ribosomes and promotes …
The structure, regulation, and function of ZAP-70 - PubMed
The tyrosine ZAP-70 (zeta-associated protein of 70 kDa) kinase plays a critical role in activating many downstream signal transduction pathways in T cells following T-cell receptor (TCR) engagement.
What Is ZAP-70? - Patient Power
2019年10月1日 · What is ZAP-70 (70-kDa zeta-associated protein), and what can it reveal about a CLL patient’s prognosis? Experts Drs. Nitin Jain, Alessandra Ferrajoli and Javier Munoz explore this prognostic marker and what role—if any—it plays in determining a treatment path.
Poor prognosis is ZAP70’ed into focus in CLL
2021年7月1日 · Studying the function of ZAP70 in primary CLL cells is problematic because specific inhibitors against this kinase do not exist, and the short life span of primary cells in culture make short interfering RNA-mediated knockdown of proteins with a long half-life difficult.
Zap-70 - SpringerLink
2018年1月1日 · The protein tyrosine kinase ZAP-70 is a crucial molecule for T-cell activation, where it orchestrates the early steps in antigen receptor signaling. This entry provides a brief overview of the structure and regulation of ZAP-70, as …
ZAP-70 Deficiency - Immune Disorders - Merck Manual Consumer Version
ZAP-70 (zeta-associated protein 70) deficiency is a genetic disorder of the immune system that results in an abnormality in T cells that prevents T cells from becoming activated to fight specific infections.
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