Rab (G-protein) - Wikipedia
网页Rab proteins are peripheral membrane proteins, anchored to a membrane via a lipid group covalently linked to an amino acid. Specifically, Rabs are anchored via prenyl groups on two cysteines in the C-terminus.
Rab proteins as membrane organizers - Nature
网页2001年2月1日 · Summarizes the intracellular localization of Rab proteins in mammalian cells. Some proteins are cell- (for example, Rab3a in neurons) or tissue-specific (for example, Rab17 in epithelia) or...
Rab proteins: the key regulators of intracellular vesicle transport
网页2014年10月15日 · Rab proteins are characterized by their distinct sub-cellular localization and regulate a wide variety of endocytic, transcytic and exocytic transport pathways. Mutations of Rabs affect cell growth, motility and other biological processes.
Rab family of small GTPases: an updated view on their …
网页2020年7月1日 · The Rab family of small GTPases regulates intracellular membrane trafficking by orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound organelles and vesicles. Like other small GTPases, Rabs cycle between two states, an active (GTP‐loaded) state and an inactive (GDP‐loaded) state, and their …
Rab family of GTPases - PubMed
网页Rab proteins represent the largest branch of the Ras-like small GTPase superfamily and there are 66 Rab genes in the human genome. They alternate between GTP- and GDP-bound states, which are facilitated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and function ….
Rab GTPases and their interacting protein partners: Structural …
网页2017年7月7日 · Rab proteins are essential switches that orchestrate the constant flow of membranes throughout the cell and provide identity to different compartments. A wealth of data has provided important clues on how …
Rab6 is required for rapid, cisternal-specific, intra-Golgi cargo ...
网页2020年10月6日 · Rab proteins, the most numerous of the small GTPases that comprise the Ras superfamily in mammals, act as binary, molecular switches that in the GTP-bound state recruit effector proteins.
Rab Family of GTPases - PMC - National Center for Biotechnology …
网页Rab proteins represent the largest branch of the Ras-like small GTPase superfamily and there are 66 Rab genes in the human genome. They alternate between GTP- and GDP-bound states, which are facilitated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and function as molecular switches in regulation of ...
Regulation of autophagy by the Rab GTPase network
网页2014年1月17日 · The Rab protein is a small GTPase that belongs to the Ras-like GTPase superfamily and regulates the vesicle traffic process. Numerous Rab proteins have been shown to be involved in various...
Rab Protein - an overview | ScienceDirect Topics
网页Rab proteins are essential molecular switches in regulating virtually all membrane trafficking steps in eukaryotic cells. Rab proteins bind two operationally defined classes of proteins.
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