Plant-parasitic nematodes: towards understanding molecular …
2017年1月12日 · Regulatory components of DAF-16 and SKN-1 identified in plant-parasitic nematodes. DAF-2 is the insulin receptor during IIS signaling.
Intestine-specific removal of DAF-2 nearly doubles lifespan in
2022年10月25日 · Using tissue-specific targeted protein degradation, we determined that intracellular DAF-2-to-DAF-16 signaling in the intestine plays a major role in lifespan regulation, while that in the...
Decoy receptor fine tunes insulin signaling in C. elegans
2020年3月16日 · In the nematode, daf-2 encodes a receptor with sequence homology to mammalian insulin receptors, which is involved in fundamental biological processes such as development and aging.
On the role of dauer in the adaptation of nematodes to a …
2021年10月27日 · INSs involved in dauer bind to insulin receptor DAF-2, which apart from the dauer signalling pathway also plays a role in ageing, fat metabolism, stress resistance and development . Forty genes encode INSs, of which 19, including DAF-28, have an agonistic effect on DAF-2, preventing dauer.
End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor ...
2021年9月10日 · In class II daf-2 alleles, these phenotypes, such as small gonads, reduced brood size, reduced motility, and reduced brood size, manifest only at 25°C during adulthood but not at lower temperatures (Ewald et al., 2018; Gems et al., 1998).
A conserved KLF-autophagy pathway modulates nematode …
2017年10月13日 · The appearance of age-associated pigments in the nematode intestine was delayed in klf-3 o/e worms compared to wild type with daf-2(e1370) mutants used as positive control, and klf-3 o/e worms...
Longevity and heavy metal resistance in daf‐2 and age‐1 …
2001年3月1日 · In the nematode CAENORHABDITIS ELEGANS, dauer formation, stress resistance, and longevity are determined in part by DAF-2 (insulin receptor-like protein), AGE-1 (phosphatidylinositol-3-OH kinase cat¬alytic subunit), and DAF-16 (forkhead transcription factor). Mutations in DAF-2 and AGE-1 result in increased resistance to heat, oxidants, and UV.
SMA-10 Is a Non-Canonical Member of the TGF-β Sma/Mab …
We also found that the lack of the insulin receptor DAF-2 eliminates the sensibility of SMA-10 defective worms to P. aeruginosa PA14 (Figure 5 E). This places DAF-2 genetically downstream of SMA-10 and suggests that the immunological role …
Analysis of long-lived C. elegans daf-2 mutants using serial …
2004年9月21日 · We have identified longevity-associated genes in a long-lived Caenorhabditis elegans daf-2 (insulin/IGF receptor) mutant using serial analysis of gene expression (SAGE), a method that efficiently quantifies large numbers of mRNA transcripts by sequencing short tags.
Figure 2. Effects of daf-16, daf-2, age-1, akt-1, akt-2, or daf-18...
Mutation of the daf-2, age-1, akt-1, or akt-2 gene induced a resistant property of nematodes to GO toxicity; however, mutation of daf-18 or daf-16 gene induced a susceptible property of...