Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, …
网页2021年6月28日 · Recently, the use of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in food and dietary supplements has markedly increased due to their advantages in higher loading capacities, higher bioavailabilities of their cargoes, and easier large-scale production.
Lipid nanoparticles for mRNA delivery - Nature Reviews Materials
网页2021年8月10日 · In this Review, we discuss the design of lipid nanoparticles for mRNA delivery and examine physiological barriers and possible administration routes for lipid nanoparticle–mRNA systems.
Let’s talk about lipid nanoparticles | Nature Reviews Materials
网页2021年2月9日 · Lipid nanoparticles are spherical vesicles made of ionizable lipids, which are positively charged at low pH (enabling RNA complexation) and neutral at physiological pH (reducing...
Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview …
网页2023年8月21日 · In this review, we introduce the main types of LNPs used in drug formulations such as liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and lipid polymer hybrid nanoparticles, focusing on their main physicochemical properties and therapeutic potential.
Lipid Nanoparticles─From Liposomes to mRNA Vaccine …
网页2021年11月23日 · Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of the COVID-19 mRNA vaccines, LNPs play a key role in effectively protecting and transporting mRNA to cells.
A careful look at lipid nanoparticle characterization ... - Nature
网页2024年1月29日 · Lipid nanoparticles (LNPs) are formulated with an ionizable lipid (DLin-MC3-DMA or ALC-0315), phospholipid (DSPC or DOPE), structural lipid (cholesterol) and helper lipid (DMG-PEG2000) at a...
Innovation of Lipid‐Based Nanoparticles: the Design and …
网页3 天之前 · Lipid-based nanoparticles (LNPs) have emerged as promising tools for precise diagnosis and treatment of CVDs, owing to their exceptional biocompatibility, modifiability, and compatibility with payloads, showcasing extensive potential for diverse applications. LNPs excel in encapsulating diverse drug compounds, protecting against drug ...
A perspective of lipid nanoparticles for RNA delivery
网页Over the last two decades, lipid nanoparticles (LNPs) have evolved as an effective biocompatible and biodegradable RNA delivery platform in the fields of nanomedicine, biotechnology, and drug delivery.
Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug …
网页2022年11月10日 · Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer membrane and secreted by most eukaryotic cells. They represent a route of intercellular communication and participate in a wide variety of physiological and pathological processes.
Lipid Nanoparticles for Drug Delivery - Wiley Online Library
网页2021年11月25日 · In this review, an overview on different classes of lipid nanoparticles, including liposomes, solid lipid nanoparticles, and nanostructured lipid carriers, is first provided, followed by the introduction of their preparation methods.
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