Hyperpolarization - an overview | ScienceDirect Topics
Several attempts have been made to combine hyperpolarization methods with UF 2D NMR, thus lowering the detection limit of complex mixture NMR analysis. In addition, the conjugation of hyperpolarization and UF 2D NMR could offer an efficient way to analyze transient changes and short-lived species in a dynamic hyperpolarized system.
Hyperpolarization - an overview | ScienceDirect Topics
2007年10月16日 · Hyperpolarization. This hyperpolarization phase also cannot be explained by an artifact such as fluorescence dequenching of the mitochondrial probe (sometimes observed when it is used in high concentration) since these events were still observable at as low as 12 nM of TMRM (Fig. 9), which is 1–2 orders less than that needed to observe fluorescence …
Hyperpolarization - an overview | ScienceDirect Topics
The membrane conductance of the NG cell decreased at the transition from the depolarization to the hyperpolarization phase and during the steady-state hyperpolarization. The latter decrease, by as much as 25%, indicates a considerable contribution of …
Hyperpolarization and sensitivity in nuclear magnetic resonance
2024年12月1日 · Whenever hyperpolarization requires additional staff, with costs of the order of $ 100/h, the implication is that the cost gain is almost always smaller than the time gain. Without stringent automation, staff costs are of course also applicable to otherwise affordable hyperpolarization techniques such as parahydrogen-induced polarization.
Afterhyperpolarization - an overview | ScienceDirect Topics
A likely explanation for this is an increase in after-hyperpolarization (AHP) seen upon increased LVGCC activity (Thibault et al., 2001) and upon aging. AHP refers to the slow hyperpolarization that often follows an action potential. Increased AHP should decrease the probability of further spike discharge inhibiting LTP formation.
Hyperpolarization of [13C]formate using parahydrogen
2024年12月1日 · The hyperpolarization methods have gained considerable attention in modern NMR and biomedical MRI in particular. MR imaging along with administration of hyperpolarized (HP) contrast agents allows one to monitor metabolic processes in vivo [ 3 ].
Afterhyperpolarization - an overview | ScienceDirect Topics
The H current (I h) is a hyperpolarization-activated, time- and voltage-dependent, nonselective cation current that when activated causes depolarization of the membrane, tending to reduce afterhyperpolarization duration, increase firing frequency, and decrease adaptation. 233 An H current is prominent in most or all large DRG neurons but in ...
Facile hyperpolarization chemistry for molecular imaging and …
2023年12月1日 · Hyperpolarization chemistry based on reversible exchange of parahydrogen, also known as Signal Amplification By Reversible Exchange (SABRE), is a particularly simple approach to attain high levels of nuclear spin hyperpolarization, which can enhance NMR and MRI signals by many orders of magnitude.
Mitochondrial hyperpolarization during chronic complex I …
2014年8月1日 · If ROT-induced Δψ hyperpolarization is primarily proton-based, it might result from an increased trans-MIM proton flux out of the matrix and/or a reduced trans-MIM proton influx into the matrix. Under conditions of ETC inhibition, Δψ hyperpolarization has been linked to reverse-mode action of CV and consumption of ATP [2], [3], [40]. When ...
Hyperpolarization and the endothelium - ScienceDirect
2023年8月1日 · Hyperpolarization initiated in the endothelium by receptor activation or local influences such as K + stimulates vasodilation by passive, radial current spread via heterocellular myoendothelial gap junctions (MEJs) and/or the release of a diffusible factor(s). In addition, the endothelium has high-input resistance and serves as an effective ...