Glucose Transporters Are Key Components of the Human Glucostat
2024年8月1日 · In this study, we confirmed GLUT1 to be the predominantly expressed glucose transporter in both adult and fetal human β-cells. In comparison, GLUT2 is detected in a small yet significant subpopulation of adult β-cells and is expressed to a greater extent in fetal β-cells.
Glucose Transporters Are Key Components of the Human Glucostat
2024年5月22日 · GLUT1 and GLUT2 have not been considered essential components of the human glucostat mechanism. A main reason is that most individuals with mutations in either of these transporters do not exhibit a diabetic phenotype (23,60,72,79). Our study challenges this notion by revealing the crucial roles of GLUT1 and GLUT2 in β-cell responsiveness to ...
The body's 'glucostat' identified - ScienceDaily
The body's 'glucostat' identified. It is the pancreatic islets that have the overall responsibility for maintaining normal blood glucose levels in our bodies, according to a new study. The ...
使用 Gen 2 GlucoSTAT 进行住院患者闭环血糖控制 - ICH GCP
2020年1月10日 · 为了使系统能够应对住院环境中将面临的广泛挑战，本研究将测试系统的新集成配置 (GlucoSTAT) 控制胰岛素敏感度极高的受试者的 PG 的能力。. 本研究的首要目标是测试控制系统在胰岛素敏感的 1 型糖尿病患者中的安全性和有效性。. 本研究的第二个目标是测试 ...
Metabolic health tracking using Ultrahuman M1 continuous …
2024年3月18日 · Continuous glucose monitoring (CGM) device adoption in non- and pre-diabetics for preventive healthcare has uncovered a paucity of benchmarking data on glycemic control and insulin resistance for...
Hypothalamic glucose-sensing mechanisms - PMC - National …
Here, we review the current literature on hypothalamic glucose-sensing mechanisms and discuss the impact of alterations of these mechanisms on the pathogenesis of diabetes. Keywords: Astrocytes, Brain, Counterregulatory responses, Diabetes, Glucose-sensing, Hypothalamus, Neurons, Obesity, Review, Tanycytes.
The Network of Glucokinase-Expressing Cells in Glucose …
2006年1月1日 · The glucose-phosphorylating enzyme glucokinase has structural, kinetic, and molecular genetic features that are ideal for its primary role as glucose sensor in a network of neuro/endocrine sentinel cells that maintain glucose homeostasis in many …
The body’s “glucostat” identified | Karolinska Institutet - KI
This indicates that the pancreatic islets have the overall responsibility for maintaining normal blood glucose levels, making them the 'glucostat' in our bodies,” says principal investigator Per-Olof Berggren, Professor at the Rolf Luft Research Centre for Diabetes and Endocrinology at Karolinska Institutet’s Department of Molecular ...
The glucostatic theory of appetite control and the risk of …
2008年11月11日 · The glucostatic theory of food intake control postulated that reduced glucose utilization in critical brain regions leads to perception and expression of hunger, and increased glucose utilization...
Arginine-vasopressin mediates counter-regulatory glucagon
2021年11月17日 · The identity of the systemic factor (s) that elevates circulating glucagon remains unknown. Here, we show that arginine-vasopressin (AVP), secreted from the posterior pituitary, stimulates glucagon secretion. Alpha-cells express high levels of the vasopressin 1b receptor (V1bR) gene (Avpr1b).
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