Suppression of Glut1 and Glucose Metabolism by Decreased Akt ... - PubMed
WEBSep 15, 2016 · Metabolic defects included reduced Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling, decreased expression of the glucose transporter Glut1 and hexokinase 2, and reduced glucose uptake. These metabolic changes correlated with increased regulatory T cell frequency and expression of PD-L1 and Gal-9 on both leukemic and stromal cells ...
Glucose Transporter-1 Cooperating with AKT Signaling Promote …
WEBJun 3, 2020 · The altered metabolic activity is regulated by series of signaling pathways, including AKT signaling that acts as a key role in glucose metabolism and shows close correlation with the malignant transformation. In this study, we aimed to elucidate the effect of GLUT1 on gastric cancer (GC) and to explore the …
GPC3-targeted CAR-T cells expressing GLUT1 or AGK exhibit
WEBMay 15, 2024 · Glucose transporter type 1 (GLUT1) and acylglycerol kinase (AGK) can boost glycolytic metabolism and activate the effector function of CD8 + T cells, respectively. In this study, we generated...
Cytokine stimulation promotes glucose uptake via ... - PubMed
WEBWe show that the hematopoietic growth factor interleukin (IL)3, maintained the glucose transporter Glut1 on the cell surface and promoted Rab11a-dependent recycling of intracellular Glut1. IL3 required phosphatidylinositol-3 kinase activity to regulate Glut1 trafficking, and activated Akt was sufficient to maintain glucose uptake and surface ...
DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma …
WEBOct 7, 2021 · Knockout of DHHC9 or mutation of GLUT1 Cys207 to serine abrogates palmitoylation and PM distribution of GLUT1, and impairs glycolysis, cell proliferation, and glioblastoma (GBM) tumorigenesis.
Glucose Transporter-1 Cooperating with AKT Signaling Promote …
WEBJun 3, 2020 · The altered metabolic activity is regulated by series of signaling pathways, including AKT signaling that acts as a key role in glucose metabolism and shows close correlation with the malignant transformation. In this study, we aimed to elucidate the effect of GLUT1 on gastric cancer (GC) and to explore the …
Pharmacological Targeting of GLUT1 to Control Autoreactive T …
WEBOct 8, 2019 · The translocation of the intracellular pool of Glut1 to the cell surface is mainly regulated by Akt. Akt activation is the result of TCR and CD28 engagement or can be activated by phosphorylated STAT5 through the IL-2 or IL-7 signaling pathways.
LncRNA HOTAIR regulates glucose transporter Glut1 expression …
WEBJan 8, 2021 · Studies suggest that proinflammatory immune response in M1 macrophages enhances expression of glucose transporter isoform 1 (Glut1), glucose-6-phosphate dehydrogenase, hexokinase, and increases...
Full article: Glucose Transporter-1 Cooperating with AKT Signaling ...
WEBHigh expression of GLUT1 has been observed in numerous solid cancers, facilitating glucose consumption for supporting tumor cell survival. The altered metabolic activity is regulated by series of signaling pathways, including AKT signaling that acts as a key role in glucose metabolism and shows close correlation with the malignant ...
GLUT1 overexpression enhances CAR T cell metabolic fitness and …
WEBJul 3, 2024 · Using mouse models of acute lymphoblastic leukemia (ALL), renal cell carcinoma (RCC), and glioblastoma (GBM), we show that enforced expression of the glucose transporter GLUT1 enhances anti-tumor efficacy and promotes favorable CAR-T cell phenotypes for two clinically relevant CAR designs, 19-28z and IL13Rα2-BBz.