Cancer epigenetics: from laboratory studies and clinical trials to ...
Jan 15, 2024 · Epigenetic dysregulation is a common feature of a myriad of human diseases, particularly cancer. Defining the epigenetic defects associated with malignant tumors has become a focus of cancer...
Targeting epigenetic regulators for cancer therapy: mechanisms …
Dec 17, 2019 · Epigenetic dysregulation is often linked to human disease, notably cancer. With the development of various drugs targeting epigenetic regulators, epigenetic-targeted therapy has been applied in...
Epigenetic mechanisms and the hallmarks of cancer: an intimate …
Jul 1, 2020 · The central role of epigenetic mechanisms in the hallmarks of cancer. Epigenetic alterations comprise DNA methylation, histone modifications, and noncoding RNAs. Ageing and environmental factors collaborate with epigenetic mechanisms …
Epigenetics and Cancer - Introduction to Epigenetics - NCBI Bookshelf
Mar 24, 2021 · The disruption of epigenetic processes has been linked to altered gene expression and to cancer initiation and progression. Recent cancer genome sequencing projects revealed that numerous epigenetic regulators are frequently mutated in various cancers.
Epigenetic mechanisms as a new approach in cancer treatment: …
Jun 18, 2018 · Recent studies indicate the broad role of epigenetic mechanisms in the initiation and development of cancers, that they are including DNA methylation, histone modifications, nucleosomes changes, non-coding RNAs.
Epigenetic regulation in the tumor microenvironment: molecular …
May 22, 2023 · A growing body of evidence suggests that the mechanisms of epigenetic modification are dysregulated in human cancers and might be excellent targets for tumor treatment....
Cancer epigenetics: an introduction - PubMed
In this chapter we provide information on various epigenetic mechanisms and their role in carcinogenesis, in particular, epigenetic modifications causing genetic changes and the potential clinical impact of epigenetic research in the future.
Cancer Epigenetics: An Overview - PubMed
Nov 22, 2022 · The integration and better knowledge of these processes will help us to improve diagnosis, prognosis, and future genetic and epigenetic therapies. Here, I present an overview of the epigenetic processes that are affected in cancer and how they contribute to the onset and progression of the disease.
Research advances on epigenetics and cancer metabolism
Feb 25, 2021 · Epigenetic mechanisms play a key role in development，cell fate decision and tumorigenesis. Chromatin modifications and its high order structure across our genome are major forms of epigenetic information，and its establishment and …
Recent advances in epigenetic anticancer therapeutics and future ...
Jan 4, 2023 · Recent studies have found that epigenetic regulation and relevant therapeutics play an irreplaceable role in the mechanism research of cancer occurrence and development and in the process of cancer treatment.
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