Topoisomerase - Wikipedia
DNA topoisomerases (or topoisomerases) are enzymes that catalyze changes in the topological state of DNA, interconverting relaxed and supercoiled forms, linked (catenated) and unlinked species, and knotted and unknotted DNA.
DNA topoisomerases: structure, function, and mechanism
DNA topoisomerases solve the topological problems associated with DNA replication, transcription, recombination, and chromatin remodeling by introducing temporary single- or double-strand breaks in the DNA.
Topoisomerase – Definition, Types, Structure, and Functions
2023年11月25日 · Topoisomerases, or DNA topoisomerases, are enzymes that create single or double-stranded nicks in DNA during its replication or transcription to relieve the stress in a supercoiled DNA molecule. Thus, topoisomerases change the topology of the DNA strand.
1.6: DNA Supercoiling and Topoisomerases - Biology LibreTexts
Type II topoisomerases actually cleave the duplex DNA in changing the linkage number. Type II topoisomerases can convert a single positive supercoil into a negative supercoil. Thus the linkage number is reduced by two (-2) in a single step.
Topoisomerase: Types, Structure, Functions, Mechanism
2023年2月27日 · Topoisomerase is an essential enzyme that aids in the DNA replication process, segregation of chromosomes, transcription, and also in recombination. It was first found by J.C. Wang in the 1970s while working on Escherichia coli. It was the type I topoisomerase.
DNA topoisomerases: Advances in understanding of cellular ...
2021年4月4日 · DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and indispensable for cellular survival due to the numerous roles they play during DNA metabolism. As we review here, current structural approaches have revealed unprecedented insights into the complex DNA-topoisomerase interaction and strand passage mechanism, …
Human topoisomerases and their roles in genome stability and ...
2022年2月28日 · DNA and RNA topological conversions by topoisomerases. One of the most common changes in DNA topology is the opening of the double helix by helicases during transcription and replication and...
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