CXCR4-activated astrocyte glutamate release via TNFα ... - Nature
2001年7月1日 · Here we show that this process follows activation of the receptor CXCR4 by the chemokine stromal cell-derived factor 1 (SDF-1). An extraordinary feature of the ensuing signaling cascade is the...
Stromal Cell-Derived Factor-1a Autocrine/Paracrine Signaling ...
2020年8月7日 · We confirmed in vitro that microglia, astrocytes, and brain endothelial cells significantly change SDF-1a and CXCR4 expression after exposure. We found that diffusion-only based mathematical models were unable to capture in vivo SDF-1a spatial distribution.
Stromal cell-derived factor-1alpha induces astrocyte ... - PubMed
Stromal cell-derived factor-1 (SDF-1), the ligand of the CXCR4 receptor, is a chemokine involved in chemotaxis and brain development that also acts as co-receptor for HIV-1 infection. We previously demonstrated that CXCR4 and SDF-1alpha are expressed in cultured type-I cortical rat astrocytes, corti …
CXCR4-activated astrocyte glutamate release via TNFalpha
Astrocytes actively participate in synaptic integration by releasing transmitter (glutamate) via a calcium-regulated, exocytosis-like process. Here we show that this process follows activation of the receptor CXCR4 by the chemokine stromal cell …
Astrocytes express functional chemokine receptors
2000年11月1日 · Astrocyte responses to SDF-1α/CXCL12 include the inhibition of forskolin-stimulated cAMP production (Zheng et al., 1999a, Bajetto et al., 1999b) and the increase of intracellular free calcium concentration (Table 1).
The SDF-1–CXCR4 signaling pathway: a molecular hub …
Recent evidence demonstrates that the chemokine stromal-cell derived factor-1 (SDF-1, also known as CXCL12) has a major role in the recruitment and retention of CXCR4 + BM cells to the neo-angiogenic niches supporting revascularization of ischemic tissue and tumor growth.
The Role of SDF-1/CXCR4/CXCR7 in Neuronal Regeneration after …
SDF-1 binds to CXCR4 activates multiple G protein-coupled pathways, e.g., both Gαi and Gβγ subunits can trigger phosphatidylinositol-3-kinase (PI3K) and its main downstream targets Akt, mitogen activated protein kinase (MAPK) as well as the nuclear transcription factor NF-κB pathway; these properties have been described in astrocytes ...
The SDF-1–CXCR4 signaling pathway: a molecular hub
2007年7月1日 · Recent evidence demonstrates that the chemokine stromal-cell derived factor-1 (SDF-1, also known as CXCL12) has a major role in the recruitment and retention of CXCR4 + BM cells to the neo-angiogenic niches supporting revascularization of …
Chemokines and their receptors in the CNS: expression of CXCL12/SDF …
2003年4月4日 · The ability of CXCL12/SDF-1 to mediate astrocyte proliferation suggests a possible role for the CXCR4, the receptor for the HIV-1 strain that become prevalent in the ADC, in the generation of gliosis.
A Dual Role for the SDF-1/CXCR4 Chemokine Receptor System in …
Our understanding of the role of the SDF-1/CXCR4 receptor system in the adult brain has been hampered, however, by the lack of information about the cellular expression of CXCR4 and SDF-1 isoforms. ... SDF-1 expression in astrocytes and microglial cells was below the detection limit. Fig. 1. Open in a new tab. Cerebral expression patterns of ...