Expansion of tumor-reactive CD8+ T cell clonotypes occurs in the spleen …
2024年9月13日 · We found that the spleen was a critical anatomic site for coordinating the differentiation of an intermediate-exhausted CD8 + T cell population into either a terminally exhausted phenotype, which comprised most tumor-infiltrating cells, or into an exhausted killer cell lectin-like receptor (KLR) phenotype that was rarely found in the tumor ...
CD4/CD8/Dendritic cell complexes in the spleen: CD8+ T cells can ...
2017年7月7日 · Motile CD8 + T cells in the spleen moved at 2.8±0.63 μm min-1, while in the LN CD8 + T cell average velocities were reported to range from 7.9 to 11.9 μm min-1 [8, 20]. Due to a large spleen size, T cell velocities in normal mice cannot be measured in vivo by TPLSM. The behavior of T cells is thus analyzed ex vivo in spleen tissue sections ...
Expansion of tumor-reactive CD8+ T cell clonotypes occurs in the spleen …
2024年9月13日 · An analogous population of exhausted KLR CD8 + T cells in human blood samples exhibited diminished tumor-trafficking ability. Collectively, our data demonstrate the critical role of antigen density within the spleen for the differentiation and expansion of T cell clonotypes in response to ICB.
Differential phenotypes of memory CD4 and CD8 T cells in the spleen …
2017年4月18日 · Using splenocytes, we have shown memory CD4-T cells that expand following systemic immunostimulatory therapies undergo rapid IFNg-mediated activation induced cell death (AICD) resulting in a net loss of total CD4-T cells which correlates with elevated PD-1 expression.
CD8 T Cells Enter the Splenic T Cell Zones Independently of CCR7, …
2015年12月1日 · These results highlight a novel role of CCR7 in regulating effector CD8 T cell migration in the spleen and demonstrate differential requirement of CCR7 for primary and secondary CD8 T cell responses to infection.
CD8 T cells enter the splenic T cell zones independently of CCR7 …
2015年12月1日 · Spleen is the most important priming site for generating CD8 T cell immunity against blood borne pathogens like Listeria monocytogenes (Lm). The anatomical structure of spleen is compartmentalized into White Pulp (WP), Which is a T cell rich area surrounded by B cell follicles, and the Red Pulp (RP), which is a blood filled area and contains ...
Immune signatures of protective spleen memory CD8 T cells
2016年11月24日 · To identify genes whose expression levels could uniquely be associated with spleen Flu-TM CD8 and could represent a signature for protection against a lethal intranasal infection, we next ...
CD4/CD8/Dendritic cell complexes in the spleen: CD8+ T cells can ...
2017年7月7日 · We here describe the first in vivo imaging of the intact spleen, aiming to evaluate the first interactions between antigen-specific CD4+, CD8+ T cells and Ag+DCs.
SLAMF7 (CD319) on activated CD8+ T cells transduces ... - Nature
4 天之前 · CD8+ T-cell responses are meticulously orchestrated processes regulated by intercellular receptor:ligand interactions. ... Tissue sections from C57BL/6 spleen snap frozen in liquid nitrogen and ...
CXCR3 regulates stem and proliferative CD8+ T cells during …
2022年1月18日 · Bangs et al. report that distinct subsets of CD8+ T cells found during chronic infection occupy distinct regions of the spleen. CXCR3 regulates differentiation of T cells but not their migration. Instead, CXCR3 promotes the interaction of T cells with ligand-producing DCs in bridging channels, resulting in effector differentiation.