Understanding CD30 biology and therapeutic targeting: a ... - Nature
2017年9月8日 · CD30 is a member of the tumor necrosis factor receptor superfamily. It is characteristically expressed in certain hematopoietic malignancies, including anaplastic large cell lymphoma and Hodgkin...
CD30 - Wikipedia
CD30 is the target of the FDA approved therapeutic brentuximab vedotin (Adcetris). It is approved for use in: Hodgkin lymphoma (HL) (brentuximab vedotin) after failure of autologous stem cell transplant (ASCT) HL in patients who are not ASCT candidates after failure of at least 2 multiagent chemotherapy regimens.
Understanding CD30 biology and therapeutic targeting: a …
2017年9月8日 · CD30 is a member of the tumor necrosis factor receptor superfamily. It is characteristically expressed in certain hematopoietic malignancies, including anaplastic large cell lymphoma and Hodgkin lymphoma, among others.
CD30: from basic research to cancer therapy - PMC - National …
CD30 is expressed by naïve T cells upon TCR triggering only following CD28 or IL-4 receptor costimulation. In contrast, CD30 expression on memory rapid cells does not require CD28 signaling. CD30 signaling on memory cells can lead to a transition from effector to central memory cells and together with Ox40 signaling to enhanced survival [49–52].
Understanding CD30 biology and therapeutic targeting: a ... - PubMed
2017年9月8日 · CD30 is a member of the tumor necrosis factor receptor superfamily. It is characteristically expressed in certain hematopoietic malignancies, including anaplastic large cell lymphoma and Hodgkin lymphoma, among others. The variable expression of CD30 on both normal and malignant lymphoid cells has focused research efforts on understanding the ...
CD30 - an overview | ScienceDirect Topics
CD30 (TNFRSF8), a transmembrane glycoprotein of the tumour necrosis factor receptor (TNFR) superfamily, is involved in signal transduction via the activation of the NF-κB pathway and the mitogen-activated protein kinases (MAPKs), ultimately modulating cell …
Human CD30 - National Center for Biotechnology Information
2018年7月2日 · CD30 + EF B cells express the B cell transcription factor PAX5, the plasmablast/plasma cell factor IRF4, and JUNB, a member of the AP-1 transcription factor family (4, 5). A fraction of them expresses activation-induced cytidine deaminase (AID), a key factor for somatic hypermutation and class switch recombination (4, 5).
Frontiers | Mechanism of action and therapeutic targeting of CD30 ...
This review will elaborate on the mechanism of CD30-mediated tumor promotion, explore the molecular factors that regulate CD30 expression and function, and search for more efficient potential therapeutic strategies for CD30+lymphomas based on BV. 2 Structure and biological function of CD30 protein
Human CD30: Structural implications from epitope mapping and …
2003年1月24日 · With its specific expression pattern and easy accessibility on the surface of H-RS cells CD30 is a valuable diagnostic marker and holds considerable promise as a target for in vivo immunotherapy. Knowledge of epitopes on the CD30 molecule is expected to facilitate the design of novel non-immunogenic anti-CD30 reagents.
CD30 is a survival factor and a biomarker for transformed human ...
2006年2月26日 · Here we show that CD30, a member of the tumor necrosis factor receptor superfamily, is expressed on transformed but not normal hES cells, and that CD30 expression protects hES cells against...