Arrestin - Wikipedia
Arrestin binding to the receptor blocks further G protein-mediated signaling and targets receptors for internalization, and redirects signaling to alternative G protein-independent pathways, such as β-arrestin signaling.
The multifaceted functions of β-arrestins and their therapeutic ...
2024年1月11日 · This review article provides a comprehensive summary of the established functions of beta-arrestins and underscores recent findings linking beta-arrestins to neurodegenerative diseases.
β−Arrestins: Structure, Function, Physiology, and Pharmacological ...
The two β-arrestins, β-arrestin-1 and -2 (systematic names: arrestin-2 and -3, respectively), are multifunctional intracellular proteins that regulate the activity of a very large number of cellular signaling pathways and physiologic functions. The two proteins were discovered for their ability to disrupt signaling via G protein-coupled ...
β -Arrestins: Structure, Function, Physiology, and ... - PubMed
The two β -arrestins, β -arrestin-1 and -2 (systematic names: arrestin-2 and -3, respectively), are multifunctional intracellular proteins that regulate the activity of a very large number of cellular signaling pathways and physiologic functions.
GPCR signaling via β-arrestin-dependent mechanisms
β-arrestin1 forms two trimeric signaling complexes following ET A R activation to induce β-catenin signaling pathways and promote cell invasion. First, β-arrestin activates Src, leading to EGFR transactivation, MAPK signaling and β-catenin stabilization via Tyr phosphorylation.
β-arrestin2: an emerging player and potential therapeutic target in ...
2024年9月30日 · β-arrestin2, a pivotal protein within the arrestin family, is localized in the cytoplasm, plasma membrane and nucleus, and regulates G protein-coupled receptors (GPCRs) signaling. Recent evidence ...
2020年9月3日 · b-arrestin orchestrates cytoskeletal changes via filamin-A and cofilin. b-arrestin affects the phosphorylation status-dependent activity of cofilin by scaffolding both LIMK and the Ser/Thr phosphatase SSH/CIN.
2023年4月7日 · Abstract - The two β-arrestins, β-arrestin-1 and -2 (systematic names: arrestin-2 and -3, respectively), are multifunctional intracellular proteins that regulate the activity of a very large number of cellular signaling pathways and physiological functions.
Catalytic activation of β-arrestin by GPCRs | Nature
2018年5月2日 · β-arrestins are critical regulator and transducer proteins for G-protein-coupled receptors (GPCRs). β-arrestin is widely believed to be activated by forming a stable and stoichiometric GPCR–β...
Molecular insights into atypical modes of β-arrestin ... - Science
2024年1月4日 · β-arrestins (βarrs) are multifunctional proteins involved in signaling and regulation of seven transmembrane receptors (7TMRs), and their interaction is driven primarily by agonist-induced receptor activation and phosphorylation.