Bronchoalveolar Lavage Fluid Protein Expression in Acute …
2017年8月7日 · Acute respiratory distress syndrome (ARDS) is associated with high mortality. We sought to identify biological pathways in ARDS that differentiate survivors from non-survivors. We studied...
Apoptotic neutrophil-mediated inflammatory ... - ScienceDirect
2023年10月1日 · DiD + cells were detected in BALF of ARDS mice, suggesting that T-NP@ApoNEs could cross the blood vessels and enter the alveoli. And the proportion of DiD + cells in the BALF of ARDS mice was significantly higher than that of healthy mice, demonstrating that the inflammatory targeting ability of ApoNEs was not affected by T-NP ( Fig. 4 L ).
Mouse Models of Acute Respiratory Distress Syndrome:
2015年8月21日 · An increase in BALF neutrophils in mice is often associated with elevated BALF levels of keratinocyte chemoattractant (KC, also known as CXCL1) and macrophage inflammatory protein 2-alpha (MIP-2α, also known as CXCL2), which are the murine analogs of the neutrophil-recruiting chemokine interleukin-8 (IL-8; Bhargava et al. 2013; Y. Xu et al. 2014).
Differential Protein Expression Profiles of Bronchoalveolar Lavage ...
The protein expression profile of the bronchioalveolar lavage fluid (BALF) directly reflects the pathological changes in the airspace milieu in ARDS. Differential BALF protein expression was observed at different time points following the onset of ARDS , as well as with differing disease severity (mild vs. severe) .
Lipopolysaccharide-induced murine lung injury results in long …
2022年6月17日 · Markers of acute inflammation including Tumor necrosis factor (TNF)-a (A) and Interleukin (IL)-6 (B) were elevated in the BALF in lipopolysaccharide (LPS)-treated mice compared to controls at...
By activating endothelium histone H4 mediates oleic acid-induced …
2025年1月6日 · Pathogenic role of histone H4 in OA induced ARDS in mice. After OA challenge, plasma histone H4 and BALF histone H4 were significantly higher than those in the control group, especially when the OA dose exceeded 300 µL/kg, as shown in Fig. 1A and B. Significant positive correlations were observed between the doses of OA (from 100 to 450 µL/kg) and histone H4 in plasma (r = 0.9706, p = 0.006 ...
ANKRD22 aggravates sepsis-induced ARDS and promotes …
2023年12月21日 · Flow cytometry results showed that the CD86 expression of macrophages was significantly upregulated in the lung tissue of LPS-ARDS or CLP-ARDS model mice, while the M1 polarization of macrophages in the lungs of both groups was significantly decreased after ANKRD22 knockdown (Fig. 4 C and D). These findings indicate that ANKRD22 promotes the ...
Phenylalanine promotes alveolar macrophage pyroptosis
2023年6月12日 · In this study, phenylalanine promoted pyroptosis of AMs, which exacerbated lung inflammation and ARDS lethality in mice. Furthermore, phenylalanine initiated the NLRP3 pathway by activating the calcium-sensing receptor (CaSR).
Resistive spontaneous breathing exacerbated lipopolysaccharide …
2024年5月6日 · In this study, RSB was combined with LPS inhalation to measure the role of spontaneous respiratory mechanical forces in ARDS. RSB resulted in a significant airway resistance increase accompanied by tidal volume decrease in ARDS mice, suggesting that spontaneous respiratory restriction reduced ventilation.
Bronchoalveolar Lavage Fluid Protein Expression in Acute …
2017年8月7日 · Acute respiratory distress syndrome (ARDS) is associated with high mortality. We sought to identify biological pathways in ARDS that differentiate survivors from non-survivors. We studied bronchoalveolar lavage fluid (BALF) from 36 …