The global market for mRNA vaccines and therapeutics is expanding due to the rising incidence of chronic illnesses ...

Here, we discuss strategies to select the best therapeutic antigen targets, to optimize the structure of IgG antibodies and to design related or new structures with additional functions.

The process is followed by computationally guided mutagenesis or evolution of the antibody sequence (hit to lead, or H2L, optimisation) to improve the binding and other properties. Although the ...

1 lineage vaccine antigen as one approach to induce enhanced neutralizing antibody responses to JN.1 and its descendent lineages. Several manufacturers (using mRNA and recombinant protein-based ...

Ada, G.L. & Byrt, P.L. Specific inactivation of antigen-reactive cells with 125 I-labelled antigen. Nature 222 , 1291–1292 (1969). Article CAS PubMed Google Scholar ...

Monoclonal antibodies are novel therapeutic agents used ... the need for daily injections with a high frequency of injection site reactions. Indirect comparative efficacy studies are fraught ...

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First-in-Human Clinical Trial of CAR T Cell Therapy With New Binding ... Antibodies Designed to Treat Variety of Blood Cancers and Disorders Nov. 16, 2023 — Immunotherapies that target the CD20 ...

For the organism it is important to replenish internal energy storages selectively and selective appetite for nutrients might uncover internal energy requirements. How is the selective uptake of a ...

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