In the image, the Shh signaling pathway has been activated in a subset of astrocytes (red). These cells produce high levels of Kir4.1 (green), a potassium channel needed to maintain proper ...

Amyotrophic lateral sclerosis (ALS) is a serious and usually fatal neurodegenerative disorder in which motor neurons deteriorate and die. | Genetics And Genomics ...

“These damages cause the cilia to stop working properly,” explains Mathias De Decker, first author of the study. “We saw that an important signaling pathway – the sonic hedgehog (Shh) signaling ...

This interaction is vital for proper guidance of developing axons. During embryonic development, Shh acts as a guidance signal, attracting axons. The team led by Charron, who also holds the Canada ...

During embryonic development, Shh acts as a guidance signal, attracting axons. The team led by Charron, who also holds the Canada Research Chair in Developmental Neurobiology, had previously ...

"This structural damage prevents proper signal transmission," says Dr. Mathias De Decker, first author. "We saw that the sonic hedgehog (Shh) pathway—a key pathway for motor neuron health ...

Several components of the hedgehog (Hh) pathway are crucial to basal cell carcinoma (BCC) tumorigenesis. Primary cilia have emerged as key organelles in Hh signal transduction in mammalian systems ...