研究发现了可用于肿瘤干预的p53-SET-PP2A反馈调节环路。研究人员设计联合应用p53激活剂和SET拮抗剂，发现两者能够产生协同抑制肿瘤的生物学效应 ...

在细胞核中，细胞色素c与蛋白质ANP32B相互作用，后者是一种组蛋白伴侣，有助于维持DNA结构并抑制酶（磷酸酶）PP2A的活性，PP2A是DNA损伤修复的主要 ...

These include a project that may produce a drug for the treatment of cancer or Alzheimer’s disease. Matthias Baumann, an expert in pharmacokinetics, heads this project, which operates internally under ...

GlobalData’s report assesses the drugs in the Protein Phosphatase 2A pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

Tumour-suppressor proteins act to alleviate the potential for cancer and tumour formation by modulating cell growth either through negative regulation of the cell cycle or by promoting apoptosis ...

DEPTAC. Based on PROTACs, or protein-targeting chimeras, D20, a dephosphorylation-targeting chimera, delivers PP1 to tau. The C-terminal tail (gray) helps the construct enter cells. [Courtesy of Xiao ...

Brian Wadzinski, associate professor of pharmacology, recently submitted a grant application to characterize pan- and phosphor-specific nanobodies for investigating MAPK and PP2A signalling.

Dr. Laura Stafman joined the faculty of the UAB Department of Surgery as an Assistant Professor in the Division of Pediatric Surgery in October 2023. She graduated from medical school at the ...