Known commonly as p53, it is a tumor suppressor gene with the power to block potentially cancerous cells from becoming malignant. But when mutated, p53 loses its cancer-fighting ability, dramatically ...
Colorectal cancer (CRC) stands as the second most common cause of cancer-related mortality globally and p53, a widely recognized tumor suppressor, contributes to the development of CRC.
The advent of large-scale sequencing in both development and disease has identified large numbers of candidate genes that may be linked to important phenotypes. Validating the function of these ...