Researchers hope to plan clinical trials of 5-fluorouracil with drugs that would enhance its RNA-damaging effects and kill ...

We discovered that lysosomes process topoisomerase 1 cleavage ... and is clinically relevant for colorectal cancer patients.” In a patient receiving chemotherapy for colorectal cancer, the ...

Doctors have long believed the cancer drug 5-fluorouracil works by damaging the building blocks of DNA, but researchers have now found that in certain cancers, it kills cells by interfering with RNA ...

Since the 1950s, a chemotherapy drug known as 5-fluorouracil has been used to treat many types of cancer, including blood ...

1 as a COVID Variant of Interest Amid Global Spread Four 'Warning Signals' of Bowel Cancer That Appear 'Up to Two Years' ...

The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis. Cell biologist Michael Overholtzer explores genes that make ...

I am a cell physiologist and my research lab uses genetics, biochemistry, advanced microscopy and synthetic biology to study: (1) fundamental lysosome biology in health and disease, and (2) ...

In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism of the ULK ...