Highly potent but poorly water-soluble drug (PWSD) candidates are common outcomes of contemporary drug discovery programmes. These lipophilic compounds often exhibit poor systemic exposure ...

Since lipids are hydrophobic, they are better soluble in organic solvents than in water. Because the lipids are buried into protein particles simple shaking of the aqueous protein solution with an ...

They're liquid at room temperature, vegetable oil for example. When you try to mix lipids with water, it's very difficult to get them to mix, so they're insoluble. So we've got various different ...

A major problem of the lipid formulations of cisplatin used so ... are notoriously difficult to enclose in liposomes because of their low water solubility and low lipophilicity.

A key microscale process in the ocean is the dietary preferences of bacteria that feed on organic molecules called lipids. The movement of carbon dioxide (CO 2) from the surface of the ocean ...

Condensates in cells, also called biomolecular condensates, behave like oil drops within water. They are made of ...

Imagine being able to see right through your skin to watch your muscles or organs in action. It sounds like science fiction, ...

"Instead of using a typical chemical dye to stain lipids, we use heavy water that is naturally participating in the metabolic activities we're interested in," added Shi. "This gives us a much ...

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a disease in which lipids (cholesterol) and other substances accumulate in plaques on the arterial wall, causing the vessels to harden and narrow, and increasing the risk of severe cardiovascular ...

Lipids are not just fuel, but a protection mechanism for cancer cells that modulates how they communicate with the immune system." Future work will determine whether this holds true for multiple ...

In AKI, immune cells known as macrophages produce lipid mediators (LMs), which are lipids with significant physiological activity that play a pivotal role in promoting and suppressing inflammation.