Nicks are potentially deleterious DNA lesions that, if not corrected, may give rise to lethal double-strand breaks. Accordingly, the total loss of DNA ligase function is lethal. DNA ligases catalyze ...

They function in vivo to repair a break in E ... The N-terminal ATP-dependent ligase domain belongs to the covalent nucleotidyltransferase enzyme superfamily that includes classic RNA/DNA ligases and ...

Deoxyribonucleic acid (DNA) is the information-carrying molecule found in all living organisms. In most animal, plant and fungal cells DNA is stored in the nucleus coiled up in thread-like ...

The DNA origami technique, whereby DNA is programmed so as to produce functional nanostructures, plays a key role in these endeavors. Teams led by LMU chemist Philip Tinnefeld have now published ...

During DNA replication, the complementary base pairing ensures faithful copying of the genetic material. In RNA, cytosine also pairs with guanine. However, RNA is typically single-stranded and serves ...

Leveraging extensive expertise in E3 ligases together with proprietary DNA-encoded libraries, Nurix has built DELigase ... Nurix’s drug discovery approach is to either harness or inhibit the natural ...

Therefore, how VGLL3 functions in tumor development remains largely obscure. In this study, the researchers report that VGLL3 ...

Authors should provide at the time of submission a short paragraph explaining why their work justifies urgent publication as a Communication. Ideally, a Full paper in Food & Function should follow ...

A research group led by Prof. GUO Caixia from the Beijing Institute of Genomics of the Chinese Academy of Sciences (CAS) and TANG Tie-Shan from the ...

Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences; Peking University International Cancer Institute; and State Key Laboratory ...