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生物通
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黏附素RadD介导具核梭杆菌在肿瘤组织定殖并促进结直肠癌进展
深入研究发现RadD能与结直肠癌细胞表面高表达的受体蛋白CD147结合介导该致病菌在肿瘤组织处的富集和定殖,同时激活细胞内PI3K–AKT–NFΚB级联信号通路,促进肿瘤细胞增殖和侵袭能力,而阻断RadD-CD147相互作用能显著减缓小鼠肠道肿瘤发生和进展(图)。
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