Transneural Therapeutics Inc. has described 5-HT2A receptor modulators reported to be useful for the treatment of depression, anxiety, substance abuse and dependence, and headache.

One of these is the 5-HT2A receptor, which has a recently discovered unique characteristic: It dampens incoming visual information, giving our brain more space for internal processes and ...

Others point to psychedelics’ chemical properties—namely their ability to strongly activate 5-HT2A receptors—as key. Cannabis has always been controversial in terms of how it fits into this ...

According to the partners, DSP-0038 combines serotonin 5-HT2A receptor antagonism and 5-HT1A receptor agonism – two well established targets for antipsychotic drugs – in a single small molecule.

Pimavanserin is a 5-HT2A inverse agonist that is FDA approved for treating Parkinson’s disease psychosis. Acadia Pharmaceuticals Inc. searched for a compound that relies on pimavanserin but with an ...